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KMID : 0385920140250030323
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Journal of the Korean Society of Emergency Medicine
2014 Volume.25 No. 3 p.323 ~ p.326
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A Case of Severe Digoxin Intoxication Treated with Digoxin Immune Fab
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Kim Seong-Tak
Lim Yong-Su
Park Won-Bin
Woo Jae-Hyuk
Jang Jae-Ho
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Abstract
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Digoxin is commonly used in treatment of various heart conditions, such as atrial fibrillation, atrial flutter, and sometimes heart failure. The therapeutic range of digoxin is narrow. Therefore, Digoxin toxicity is common. However, severe digoxin intoxication is uncommon. Many cases involving application of Digoxin immune Fab for digoxin intoxication in other countries have been reported. However, no cases have been reported in Korea. We reported on one case, a 34-year-old male with acute and severe digoxin intoxication who was treated with digibind.. His chief complaint was gastrointestinal symptoms, including nausea and vomiting. Electrocardiography (ECG) showed third degree atrioventricular (AV) block. After an infusion of digibind., third degree AV block rhythm waschanged to first degree AV block. Nowadays, we can obtain a digoxin antidote from the national poisoning information center. Therefore, we should actively consider application of Digoxin immune Fab in patients with severe digoxin intoxication.
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KEYWORD
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Digoxin, Digoxin antibodies Fab fragments
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